tag:blogger.com,1999:blog-67323250505456326702024-03-14T04:36:51.821-07:00Intoxicacion por SalicilatosEn este blogg podran encontrar los documentos, videos, presentación, gráficas, resumenes y bibliografía, de la exposición de bioquímica de Intoxicación por Salicilatos.intoxicación por salicilatoshttp://www.blogger.com/profile/11916964230815399927noreply@blogger.comBlogger7125tag:blogger.com,1999:blog-6732325050545632670.post-55138796948256385682011-11-08T16:00:00.000-08:002011-11-08T16:00:02.651-08:00Estado Ácido Base<div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhU7ssb0Vh4rsEZCuBX6nYaKW0Xjb12-XwoVtUtsa0rgG2TwwbKJmnXBgnriycJUx0kPoGcb8pyvHDb4wc1A799PlSWRewOW-KuxABKKjOp8Pmy_YWvPuKR8Aa6_yIgsvGVjU52WyVEM3Bn/s1600/Grafica-Mateo.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="240" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhU7ssb0Vh4rsEZCuBX6nYaKW0Xjb12-XwoVtUtsa0rgG2TwwbKJmnXBgnriycJUx0kPoGcb8pyvHDb4wc1A799PlSWRewOW-KuxABKKjOp8Pmy_YWvPuKR8Aa6_yIgsvGVjU52WyVEM3Bn/s320/Grafica-Mateo.jpg" width="320" /></a></div>intoxicación por salicilatoshttp://www.blogger.com/profile/11916964230815399927noreply@blogger.com1tag:blogger.com,1999:blog-6732325050545632670.post-21074399497032832962011-11-08T15:58:00.000-08:002011-11-08T15:58:06.471-08:00Gráfico Integración Metabolica<div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhWWZEKL06Ya2i5ZpgllNKKxy1RyBbRMwYmeTWT95xVfGvUw-w4OyuEYZW0k-ALX-VWhiCMLVgKA7RHcU7481f705GHI7HJetmHxyOiC2JySwjKXnKPB_LukWZ2C3TJkXLCpMHUFfHD5wh7/s1600/Grafica-Efectos-metabolicos.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="240" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhWWZEKL06Ya2i5ZpgllNKKxy1RyBbRMwYmeTWT95xVfGvUw-w4OyuEYZW0k-ALX-VWhiCMLVgKA7RHcU7481f705GHI7HJetmHxyOiC2JySwjKXnKPB_LukWZ2C3TJkXLCpMHUFfHD5wh7/s320/Grafica-Efectos-metabolicos.jpg" width="320" /></a></div>intoxicación por salicilatoshttp://www.blogger.com/profile/11916964230815399927noreply@blogger.com1tag:blogger.com,1999:blog-6732325050545632670.post-20011403731760256472011-11-08T15:30:00.000-08:002011-11-08T15:30:21.367-08:00Efectos por Sistemas<style>
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<div align="center" class="MsoListParagraph" style="text-align: center;"><b style="mso-bidi-font-weight: normal;"><span lang="ES" style="color: #0080ff; font-family: Arial; font-size: 16.0pt; mso-ansi-language: ES; mso-effects-reflection-align: bottomleft; mso-effects-reflection-angdirection: 5400000; mso-effects-reflection-angfadedirection: 5400000; mso-effects-reflection-anglekx: 0; mso-effects-reflection-angleky: 0; mso-effects-reflection-dpidistance: .079pt; mso-effects-reflection-dpiradius: 1.0pt; mso-effects-reflection-pctalphaend: 0%; mso-effects-reflection-pctalphastart: 28.0%; mso-effects-reflection-pctendpos: 45.0%; mso-effects-reflection-pctstartpos: 0%; mso-effects-reflection-pctsx: 100.0%; mso-effects-reflection-pctsy: -100.0%; mso-style-textfill-fill-gradientfill-shade-linearshade-angle: 5400000; mso-style-textfill-fill-gradientfill-shade-linearshade-fscaled: no; mso-style-textfill-fill-gradientfill-shadetype: linear; mso-style-textfill-fill-gradientfill-stoplist: "0 \#381563 7 100000 shade=20000 satm=245000\,43000 \#7B34D2 7 100000 satm=255000\,48000 \#7230C3 7 100000 shade=85000 satm=255000\,100000 \#381563 7 100000 shade=20000 satm=245000"; mso-style-textfill-type: gradient; mso-style-textoutline-fill-alpha: 100.0%; mso-style-textoutline-fill-color: #5C437A; mso-style-textoutline-fill-colortransforms: "shade=50000 satm=120000"; mso-style-textoutline-fill-themecolor: accent4; mso-style-textoutline-outlinestyle-align: center; mso-style-textoutline-outlinestyle-compound: simple; mso-style-textoutline-outlinestyle-dash: solid; mso-style-textoutline-outlinestyle-dpiwidth: .709pt; mso-style-textoutline-outlinestyle-join: round; mso-style-textoutline-outlinestyle-linecap: flat; mso-style-textoutline-outlinestyle-pctmiterlimit: 0%; mso-style-textoutline-type: solid; text-transform: uppercase;">EFECTOS POR SISTEMAS</span></b><b style="mso-bidi-font-weight: normal;"><span style="font-family: Arial; font-size: 16.0pt; mso-effects-reflection-align: bottomleft; mso-effects-reflection-angdirection: 5400000; mso-effects-reflection-angfadedirection: 5400000; mso-effects-reflection-anglekx: 0; mso-effects-reflection-angleky: 0; mso-effects-reflection-dpidistance: .079pt; mso-effects-reflection-dpiradius: 1.0pt; mso-effects-reflection-pctalphaend: 0%; mso-effects-reflection-pctalphastart: 28.0%; mso-effects-reflection-pctendpos: 45.0%; mso-effects-reflection-pctstartpos: 0%; mso-effects-reflection-pctsx: 100.0%; mso-effects-reflection-pctsy: -100.0%; mso-style-textfill-fill-gradientfill-shade-linearshade-angle: 5400000; mso-style-textfill-fill-gradientfill-shade-linearshade-fscaled: no; mso-style-textfill-fill-gradientfill-shadetype: linear; mso-style-textfill-fill-gradientfill-stoplist: "0 \#381563 7 100000 shade=20000 satm=245000\,43000 \#7B34D2 7 100000 satm=255000\,48000 \#7230C3 7 100000 shade=85000 satm=255000\,100000 \#381563 7 100000 shade=20000 satm=245000"; mso-style-textfill-type: gradient; mso-style-textoutline-fill-alpha: 100.0%; mso-style-textoutline-fill-color: #5C437A; mso-style-textoutline-fill-colortransforms: "shade=50000 satm=120000"; mso-style-textoutline-fill-themecolor: accent4; mso-style-textoutline-outlinestyle-align: center; mso-style-textoutline-outlinestyle-compound: simple; mso-style-textoutline-outlinestyle-dash: solid; mso-style-textoutline-outlinestyle-dpiwidth: .709pt; mso-style-textoutline-outlinestyle-join: round; mso-style-textoutline-outlinestyle-linecap: flat; mso-style-textoutline-outlinestyle-pctmiterlimit: 0%; mso-style-textoutline-type: solid; text-transform: uppercase;"></span></b></div><div class="MsoNormal" style="text-align: justify; text-justify: inter-ideograph;"><br />
</div><div class="MsoNormal" style="margin-left: 18.0pt; text-align: justify; text-justify: inter-ideograph;"><b style="mso-bidi-font-weight: normal;"><span lang="ES" style="color: #0080ff; font-family: Arial; mso-ansi-language: ES;">Cardiológico - Hematológico
</span></b><b style="mso-bidi-font-weight: normal;"><span style="color: #0080ff; font-family: Arial;"></span></b></div><div style="margin-left: 35.45pt; mso-list: l4 level1 lfo8; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><span lang="ES" style="font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span><span lang="ES" style="font-family: Arial;">La función sobre la sangre se da principalmente a nivel de la inhibición del Tromboxano 2. Éste es el agregante plaquetario más fuerte que posee el cuerpo<span style="mso-spacerun: yes;"> </span>por ende la función de los diversos salicilatos antiagregantes se da a nivel de la membrana de la plaqueta, que es rica en Tromboxano Sintetasa para la formación rápida de éstos frente a una herida o una hemorragia, manteniendo la hemostasia, causando un efecto antitrombotico. Los efectos de los salicilatos desaparecen alrededor de las 36 horas, y en caso de una dosis muy alta hay un riesgo de ejercer un efecto inhibitorio sobre la hemostasis dependiente de la vitamina K, con lo que se altera la síntesis de protrombina, resultando una hipoprotrombinemia. </span></div><div style="margin-left: 35.45pt; mso-list: l4 level1 lfo8; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><span lang="ES" style="font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span><span lang="ES" style="font-family: Arial;">Durante una intoxicación sólo de salicilatos se ha demostrado que es peligroso sobre todo en pacientes con problemas cardiacos, produciendo un estado de taquicardia por la baja de presión general en el cuerpo. El corazón recibe un estímulo de los órganos distales que le indican que no está llegando la suficiente sangre induciendo un estado taquicárdico.</span></div><div style="margin-left: 35.45pt; mso-list: l4 level1 lfo8; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><span lang="ES" style="font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span><span lang="ES" style="font-family: Arial;">También hay un riesgo permanente de desmayos agudos por el estado de hipotensión<span style="mso-spacerun: yes;"> </span>marcada que se presenta en el cuerpo.</span></div><div style="margin-left: 35.45pt; mso-list: l4 level1 lfo8; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><span lang="ES" style="font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span><span lang="ES" style="font-family: Arial;">En casos crónicos de hematotoxicidad la trombocitopenia secundaria a la aspirina ha sido descrita en el 27% de 95 casos de desórdenes hematológicos inducidos por la aspirina. La incidencia de anemia aplastica y agranulocitica fue del 13.6% y 10%, respectivamente.</span></div><div class="MsoListParagraph" style="text-align: justify; text-justify: inter-ideograph;"><br />
</div><div class="MsoNormal" style="margin-left: 18.0pt; text-align: justify; text-justify: inter-ideograph;"><b style="mso-bidi-font-weight: normal;"><span lang="ES" style="color: #0080ff; font-family: Arial; mso-ansi-language: ES;">Acido base - Renal
y respiratorio</span></b><b style="mso-bidi-font-weight: normal;"><span style="color: #0080ff; font-family: Arial;"></span></b></div><div class="MsoListParagraph" style="text-align: justify; text-justify: inter-ideograph;"><br />
</div><div class="MsoNormal" style="text-align: justify; text-justify: inter-ideograph;"><span style="font-family: Arial;">La intoxicación por salicilatos cuenta con 2 fases:<span style="color: black; mso-bidi-font-weight: bold;"></span></span></div><div class="MsoListParagraphCxSpFirst" style="mso-add-space: auto; mso-list: l1 level1 lfo2; mso-margin-bottom-alt: auto; mso-margin-top-alt: auto; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><span style="color: black; font-family: Arial; mso-fareast-font-family: Arial;"><span style="mso-list: Ignore;">1.<span style="font: 7.0pt "Times New Roman";"> </span></span></span><span style="color: black; font-family: Arial; mso-fareast-font-family: "Times New Roman";">Alcalosis respiratoria: dura aproximadamente 12 horas </span></div><div class="MsoListParagraphCxSpLast" style="mso-add-space: auto; mso-list: l1 level1 lfo2; mso-margin-bottom-alt: auto; mso-margin-top-alt: auto; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><span style="color: black; font-family: Arial; mso-fareast-font-family: Arial;"><span style="mso-list: Ignore;">2.<span style="font: 7.0pt "Times New Roman";"> </span></span></span><span style="color: black; font-family: Arial; mso-fareast-font-family: "Times New Roman";">Acidosis metabólica.</span></div><div class="MsoNormal" style="mso-margin-bottom-alt: auto; mso-margin-top-alt: auto; text-align: justify; text-justify: inter-ideograph;"><span style="color: black; font-family: Arial; mso-fareast-font-family: "Times New Roman";">Alcalosis respiratoria: Los salicilatos estimulan el centro respiratorio en el bulbo raquídeo (tallo cerebral) llevando al paciente a presentar hiperventilación. Esto aumenta la pérdida insensible de ácido carbónico, que mantenida en el tiempo con lleva a un estado de alcalosis.</span></div><div class="MsoNormal" style="mso-margin-bottom-alt: auto; mso-margin-top-alt: auto; text-align: justify; text-justify: inter-ideograph;"><span style="color: black; font-family: Arial; mso-fareast-font-family: "Times New Roman";">Acidosis metabólica: esta es explicada por varios fenómenos:</span></div><div class="MsoNormal" style="mso-margin-bottom-alt: auto; mso-margin-top-alt: auto; text-align: justify; text-justify: inter-ideograph;"><span style="color: black; font-family: Arial; mso-fareast-font-family: "Times New Roman";">Acumulación de ácido fosfórico y ácido sulfúrico secundarios a la falla renal.</span></div><div class="MsoNormal" style="mso-margin-bottom-alt: auto; mso-margin-top-alt: auto; text-align: justify; text-justify: inter-ideograph;"><span style="color: black; font-family: Arial; mso-fareast-font-family: "Times New Roman";">Desacoplamiento de la cadena transportadora de electrones y como consecuencia de esto a la interferencia del ciclo de Krebs, se limita la producción de ATP, se acumula ácido pirúvico y ácido láctico, pues la célula opta por aumentar la glucólisis cuyo producto principal es el piruvato, que en condiciones anaerobias se desvía hacia la producción de lactato. </span></div><div class="MsoNormal" style="mso-margin-bottom-alt: auto; mso-margin-top-alt: auto; text-align: justify; text-justify: inter-ideograph;"><span style="color: black; font-family: Arial; mso-fareast-font-family: "Times New Roman";">Los salicilatos a su vez inducen el catabolismo de ácidos grasos, lo que aumenta la cantidad de cuerpos cetónicos, ácido acetoacético, acetona y ácido B-hidroxibuírico. </span></div><div class="MsoNormal" style="mso-margin-bottom-alt: auto; mso-margin-top-alt: auto; text-align: justify; text-justify: inter-ideograph;"><span style="color: black; font-family: Arial; mso-fareast-font-family: "Times New Roman";">También el patrón de respiración se ve alterado por edema pulmonar inducido por salicilatos además de la depresión del centro respiratorio en el SNC originado por la sobredosis y por la fatiga originada gracias a la hiperventilación prolongada, lo que genera acidosis respiratoria. </span></div><div class="MsoNormal" style="mso-margin-bottom-alt: auto; mso-margin-top-alt: auto; text-align: justify; text-justify: inter-ideograph;"><span style="color: black; font-family: Arial; mso-fareast-font-family: "Times New Roman";">Todo esto sumado contribuye al estado acidótico del paciente intoxicado,<span style="mso-spacerun: yes;"> </span>dando<span style="mso-spacerun: yes;"> </span>como resultado el aumento del<span style="mso-spacerun: yes;"> </span>anion gap</span><span style="font-family: Arial;">. </span><span style="color: black; font-family: Arial; mso-fareast-font-family: "Times New Roman";">En vista de que los salicilatos en dosis tóxicas actúan como desacopladores de la cadena transportadora de electrones la temperatura del paciente aumenta hasta llegar a la fiebre. </span></div><div class="MsoNormal" style="text-align: justify; text-justify: inter-ideograph;"><br />
</div><div class="MsoNormal" style="text-align: justify;"><b><span lang="ES" style="color: #3366ff; font-family: Arial;">GastroIntestinal</span></b><b style="mso-bidi-font-weight: normal;"><span style="color: #3366ff; font-family: Arial;"></span></b></div><div class="MsoListParagraph" style="text-align: justify; text-justify: inter-ideograph;"><br />
</div><div class="MsoNormal" style="text-align: justify; text-justify: inter-ideograph;"><span lang="ES" style="font-family: Arial; mso-ansi-language: ES;">La ingestión de salicilatos puede causar malestar epigástrico, náuseas, vómito, úlcera gástrica, la exacerbación de los síntomas de la úlcera péptica (ardor de estómago, dispepsia), hemorragia gastrointestinal y gastritis erosiva. </span></div><div style="text-align: justify; text-justify: inter-ideograph;"><span lang="ES" style="font-family: Arial;">Las prostaglandinas se ocupan de mantener la integridad y proliferación de la mucosa gástrica, al asegurarle un adecuado riego sanguíneo. La mucosa gástrica es uno de los mecanismos de protección del estómago frente a los agentes agresivos como el ácido clorhídrico y la pepsina. Entonces, los AINEs, al inhibir a las PG, dejan a la mucosa gástrica vulnerable frente al ácido del estómago y <span style="mso-spacerun: yes;"> </span>aumenta el riesgo de sufrir erosiones y úlceras.</span></div><div class="MsoNormal" style="text-align: justify; text-justify: inter-ideograph;"><span lang="ES" style="font-family: Arial; mso-ansi-language: ES;">Estos efectos ocurren principalmente con salicilatos acetilados, debido a que los salicilatos no acetilados carecen de la capacidad para acetilar la ciclooxigenasa y por lo tanto para inhibir de forma irreversible <span style="mso-spacerun: yes;"> </span>su actividad.</span></div><div class="MsoNormal" style="text-align: justify; text-justify: inter-ideograph;"><span lang="ES" style="font-family: Arial; mso-ansi-language: ES;">La gastroscopia de sujetos tratados crónicamente con acido acetil salicílico a menudo revela lesiones discretas ulcerosa y hemorrágica de la mucosa gástrica. En muchos casos se observan múltiples lesiones hemorrágicas con áreas bien delimitadas de necrosis. La ingestión diaria de dosis de<span style="mso-spacerun: yes;"> </span>aspirina (4 o 5 g) puede llegar a inducir sangrado con una pérdida de sangre fecal promedio de entre 3 y 8 ml por día, en comparación con aproximadamente 0,6 ml por día en sujetos no tratados. Esto puede conducir a la aparición de anemia. La incidencia de sangrado puede ser mayor con salicilatos que se disuelven lentamente y con el depósito de partículas en los pliegues de la mucosa gástrica.</span></div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><b style="mso-bidi-font-weight: normal;"><span style="color: #3366ff; font-family: Arial; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">Efectos Hepáticos</span></b></div><div class="MsoNormal"><br />
</div><div class="MsoNormal" style="text-align: justify; text-justify: inter-ideograph;"><span lang="ES" style="font-family: Arial; mso-ansi-language: ES;">Los salicilatos pueden causar daño hepático, por lo general en pacientes tratados con altas dosis, en concentraciones plasmáticas de más de 150 mg/ Kg. La lesión no es un efecto agudo, sino que su inicio ocurre después de varios meses de tratamiento. Generalmente no hay síntomas, simplemente un aumento de los niveles séricos de las transaminasas hepáticas (AST y ALT), pero algunos pacientes notan molestias en el hipocondrio derecho y dolor abdominal. La Ictericia manifiesta es poco común y la lesión es generalmente reversible con la suspensión de los salicilatos. Sin embargo, es importante anotar la contraindicación del luso de salicilatos en pacientes con enfermedad hepática crónica y en algunos otros pacientes donde se puede poner de manifiesto<span style="mso-spacerun: yes;"> </span>la aparición de enfermedades como el síndrome de Reye.</span></div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><b style="mso-bidi-font-weight: normal;"><span style="color: #3366ff; font-family: Arial; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">Efectos Metabólicos</span></b></div><div class="MsoNormal"><br />
</div><div class="MsoNormal" style="text-align: justify; text-justify: inter-ideograph;"><span style="font-family: Arial; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">Grandes<span style="mso-spacerun: yes;"> </span>dosis de salicilatos pueden causar hiperglucemia y glucosuria, y agotar el glucógeno muscular y hepático; estos efectos se explican por la liberación de epinefrina (adrenalina). Estas dosis reducen el metabolismo aerobio de la glucosa, incrementan la actividad de la glucosa 6 fosfatasa y promueven la actividad de los glucocorticoides.</span></div><div class="MsoNormal" style="text-align: justify; text-justify: inter-ideograph;"><br />
</div><div class="MsoNormal" style="text-align: justify; text-justify: inter-ideograph;"><span style="font-family: Arial; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi;">Se da un balance de nitrógeno negativo, caracterizado por aminoaciduria, por la acción de la actividad aumentada de los adrenocorticoides como el cortisol, que aumentan el catabolismo proteico aumentando la excreción de productos nitrogenados (como la úrea).</span></div><div class="MsoNormal" style="text-align: justify; text-justify: inter-ideograph;"><br />
</div><div class="MsoNormal" style="text-align: justify; text-justify: inter-ideograph;"><span lang="ES" style="font-family: Arial; mso-ansi-language: ES;">Los salicilatos reducen la lipogénesis, bloqueando la</span><span lang="ES" style="font-family: Arial; mso-ansi-language: ES; mso-fareast-font-family: "Times New Roman";"> síntesis de ácidos grasos libres a partir de acetato. La liberación de la epinefrina estimula la lipólisis en las células grasas y la liberación de largas cadenas de ácidos grasos, los cuales compiten con el salicilato por sus sitios de unión a la albúmina. Todos estos efectos conducen a la entrada cada vez mayor de ácidos grasos en el músculo y el hígado y de su oxidación al interior. Como resultado de esto, las concentraciones en plasma de ácidos grasos libres, fosfolípidos y colesterol disminuyen. La oxidación de cuerpos cetónicos se incrementa.</span><span lang="ES" style="font-family: Arial; mso-ansi-language: ES;"> (Todo lo anterior es muy raro verlo en la clínica).</span></div><div class="MsoNormal" style="text-align: justify; text-justify: inter-ideograph;"><br />
</div><div class="MsoNormal" style="margin-left: 18.0pt; text-align: justify; text-justify: inter-ideograph;"><b style="mso-bidi-font-weight: normal;"><span lang="ES" style="color: #0080ff; font-family: Arial; mso-ansi-language: ES;">Neurológico </span></b><b style="mso-bidi-font-weight: normal;"><span style="color: #0080ff; font-family: Arial;"></span></b></div><div class="MsoNormal" style="margin-right: 48.95pt; text-align: justify; text-justify: inter-ideograph;"><br />
</div><div class="MsoListParagraphCxSpFirst" style="margin-bottom: .0001pt; margin-bottom: 0cm; margin-left: 14.2pt; margin-right: 2.45pt; margin-top: 0cm; mso-add-space: auto; mso-list: l2 level1 lfo7; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><span style="font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span><span style="font-family: Arial;">El desacoplamiento de la cadena oxidativa causa fiebre que de ser por encima de los 42º C puede producir daño neurológico o muerte. </span></div><div class="MsoListParagraphCxSpMiddle" style="margin-bottom: .0001pt; margin-bottom: 0cm; margin-left: 14.2pt; margin-right: 2.45pt; margin-top: 0cm; mso-add-space: auto; mso-list: l2 level1 lfo7; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><span style="font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span><span style="font-family: Arial;">La fiebre puede inducir convulsiones en pacientes epilépticos y activar algunas enfermedades desmielinizantes.</span></div><div class="MsoListParagraphCxSpMiddle" style="margin-left: 14.2pt; mso-add-space: auto; mso-list: l2 level1 lfo7; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><span style="font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span><span style="font-family: Arial;">La<span style="mso-spacerun: yes;"> </span>hipoglicemia no es generalizada, porque aunque la glucosa sérica está en sus niveles normales, encontramos hipoglucemia en el liquido cefalorraquídeo;<span style="mso-spacerun: yes;"> </span>A este nivel, va a actuar primero como estimulante y luego como depresor. Estimula, primero, el centro bulbar y el del vomito. Luego, la depresión será sensorial. </span></div><div class="MsoListParagraphCxSpLast" style="margin-left: 14.2pt; mso-add-space: auto; mso-list: l2 level1 lfo7; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><span style="font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span><span style="font-family: Arial;">Debido a la acidosis metabólica en una etapa avanzada de la intoxicación, hay aumento de la penetración del salicilato en el SNC. Se explica porque, parece que en presencia de un medio acido se favorece el paso de salicilatos hacia el espacio intracelular, sobre todo en el cerebro, y esto se debe al estado no polar de las moléculas del fármaco en dicho ambiente.</span></div><div class="MsoNormal" style="text-align: justify; text-justify: inter-ideograph;"><br />
</div><div class="MsoListParagraph" style="margin-left: 14.2pt; mso-add-space: auto; mso-list: l2 level1 lfo7; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><span style="font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span><span style="font-family: Arial;">Se desencadenan por eso diferentes síntomas a nivel del SNC:</span></div><ol start="1" style="margin-top: 0cm;" type="1"><li class="MsoNormal" style="mso-list: l8 level1 lfo6; tab-stops: list 36.0pt; text-align: justify; text-justify: inter-ideograph;"><span style="font-family: Arial;">Hiperventilación.</span></li>
<li class="MsoNormal" style="mso-list: l8 level1 lfo6; tab-stops: list 36.0pt; text-align: justify; text-justify: inter-ideograph;"><span style="font-family: Arial;">Hiperpirexia<span style="mso-spacerun: yes;"> </span>o fiebre</span></li>
<li class="MsoNormal" style="mso-list: l8 level1 lfo6; tab-stops: list 36.0pt; text-align: justify; text-justify: inter-ideograph;"><span style="font-family: Arial;">Vomito duradero.</span></li>
<li class="MsoNormal" style="mso-list: l8 level1 lfo6; tab-stops: list 36.0pt; text-align: justify; text-justify: inter-ideograph;"><span style="font-family: Arial;">Alteraciones en la visión: Diplopía.</span></li>
<li class="MsoNormal" style="mso-list: l8 level1 lfo6; tab-stops: list 36.0pt; text-align: justify; text-justify: inter-ideograph;"><span style="font-family: Arial;">Alteraciones auditivas: hipoacusia, tinnitus, vértigo, siendo las causas el Incremento de la presión en cóclea y laberinto que origina una degeneración de las células auditivas, <br />
o puede haber un sangrado por vasoconstricción de la microvasculatura auditiva.</span></li>
<li class="MsoNormal" style="mso-list: l8 level1 lfo6; tab-stops: list 36.0pt; text-align: justify; text-justify: inter-ideograph;"><span style="font-family: Arial;">Sueño constante, estupor, delirio, confusión y alucinaciones.</span></li>
<li class="MsoNormal" style="mso-list: l8 level1 lfo6; tab-stops: list 36.0pt; text-align: justify; text-justify: inter-ideograph;"><span style="font-family: Arial;">Comportamiento agresivo y crisis epilépticas.</span></li>
<li class="MsoNormal" style="mso-list: l8 level1 lfo6; tab-stops: list 36.0pt; text-align: justify; text-justify: inter-ideograph;"><span style="font-family: Arial;">Posición en descerebración, perdida de la función muscular.</span></li>
<li class="MsoNormal" style="mso-list: l8 level1 lfo6; tab-stops: list 36.0pt; text-align: justify; text-justify: inter-ideograph;"><span style="font-family: Arial;">Edema cerebral: de tipos citotóxico, vasogénico e intersticial. El principal es el citotóxico, la barrera hematoencefálica permanece inmodificada pero se caracteriza por una alteración en el metabolismo celular. Como resultado, hay un mal funcionamiento de la bomba sodio/potasio de las celulas gliales, promoviendo una retención de agua y de sodio.</span></li>
<li class="MsoNormal" style="mso-list: l8 level1 lfo6; tab-stops: list 36.0pt; text-align: justify; text-justify: inter-ideograph;"><span style="font-family: Arial;">Coma y colapso cardio-respiratorio.</span></li>
</ol><div class="MsoNormal" style="text-align: justify; text-justify: inter-ideograph;"><br />
</div><div class="MsoNormal" style="margin-left: 18.0pt; text-align: justify; text-justify: inter-ideograph;"><b style="mso-bidi-font-weight: normal;"><span lang="ES" style="color: #0080ff; font-family: Arial; mso-ansi-language: ES;">Sd. Reyé
</span></b><b style="mso-bidi-font-weight: normal;"><span style="color: #0080ff; font-family: Arial;"></span></b></div><div class="MsoListParagraphCxSpFirst" style="text-align: justify; text-justify: inter-ideograph;"><br />
</div><div class="MsoListParagraphCxSpMiddle" style="margin-left: 14.2pt; mso-add-space: auto; mso-layout-grid-align: none; mso-list: l5 level1 lfo3; text-align: justify; text-autospace: none; text-indent: -18.0pt; text-justify: inter-ideograph;"><span class="apple-style-span"><span style="color: black; font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span></span><span class="apple-style-span"><span style="color: black; font-family: Arial;">Suele aparecer en un niño sano una enfermedad febril predominante, infección de vías respiratorias altas o la varicela seguida de un intervalo en que el niño parece haberse recuperado. </span></span></div><div class="MsoListParagraphCxSpMiddle" style="margin-left: 14.2pt; mso-add-space: auto; mso-layout-grid-align: none; mso-list: l5 level1 lfo3; text-align: justify; text-autospace: none; text-indent: -18.0pt; text-justify: inter-ideograph;"><span class="apple-style-span"><span style="color: black; font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span></span><span class="apple-style-span"><span style="color: black; font-family: Arial;">Entonces surgen vómitos bruscos persistentes 5 a 7 días después del comienzo del proceso viral. Al mismo tiempo que los vómitos o unas horas después pueden aparecer delirio y estupor. </span></span></div><div class="MsoListParagraphCxSpMiddle" style="margin-left: 14.2pt; mso-add-space: auto; mso-layout-grid-align: none; mso-list: l5 level1 lfo3; text-align: justify; text-autospace: none; text-indent: -18.0pt; text-justify: inter-ideograph;"><span class="apple-style-span"><span style="color: black; font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span></span><span class="apple-style-span"><span style="color: black; font-family: Arial;">Los síntomas neurológicos pueden agravarse rápidamente acabando en convulsiones coma y muerte, no hay signos neurológicos focales. </span></span></div><div class="MsoListParagraphCxSpMiddle" style="margin-left: 14.2pt; mso-add-space: auto; mso-layout-grid-align: none; mso-list: l5 level1 lfo3; text-align: justify; text-autospace: none; text-indent: -18.0pt; text-justify: inter-ideograph;"><span class="apple-style-span"><span style="color: black; font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span></span><span class="apple-style-span"><span style="color: black; font-family: Arial;">Hay agrandamiento moderado del hígado y alteración de las pruebas de función hepática; el enfermo no tiene ictericia.</span></span></div><div class="MsoListParagraphCxSpMiddle" style="margin-left: 14.2pt; mso-add-space: auto; mso-layout-grid-align: none; mso-list: l5 level1 lfo3; text-align: justify; text-autospace: none; text-indent: -18.0pt; text-justify: inter-ideograph;"><span style="color: black; font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span><span style="font-family: Arial;">El patrón respiratorio suele ser anormal y <b><i>se </i></b>caracteriza por respiraciones rápidas; respiración de kussmaul, profundas e irregulares. <span style="color: black;"></span></span></div><div class="MsoListParagraphCxSpMiddle" style="margin-left: 14.2pt; mso-add-space: auto; mso-layout-grid-align: none; mso-list: l5 level1 lfo3; text-align: justify; text-autospace: none; text-indent: -18.0pt; text-justify: inter-ideograph;"><span style="font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span><span style="font-family: Arial;">Las pupilas están frecuentemente dilatadas y suelen reaccionar de forma perezosa, no siendo habitual la observación de papiledema. </span></div><div class="MsoListParagraphCxSpMiddle" style="margin-left: 14.2pt; mso-add-space: auto; mso-layout-grid-align: none; mso-list: l5 level1 lfo3; text-align: justify; text-autospace: none; text-indent: -18.0pt; text-justify: inter-ideograph;"><span style="font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span><span style="font-family: Arial;">En general las manifestaciones clínicas se relacionan con la edad:</span></div><div class="MsoListParagraphCxSpMiddle" style="margin-left: 1.0cm; mso-add-space: auto; mso-layout-grid-align: none; mso-list: l7 level1 lfo4; text-align: justify; text-autospace: none; text-indent: -18.0pt; text-justify: inter-ideograph;"><span style="font-family: "Courier New"; mso-fareast-font-family: "Courier New";"><span style="mso-list: Ignore;">o<span style="font: 7.0pt "Times New Roman";"> </span></span></span><span style="font-family: Arial;">En el lactante los hallazgos iniciales más habituales son la diarrea, los vómitos ocasionales, crisis convulsivas, así como trastornos del ritmo respiratorio y síntomas derivados de la hipoglucemia.</span></div><div class="MsoListParagraphCxSpMiddle" style="margin-left: 1.0cm; mso-add-space: auto; mso-layout-grid-align: none; mso-list: l7 level1 lfo4; text-align: justify; text-autospace: none; text-indent: -18.0pt; text-justify: inter-ideograph;"><span class="apple-style-span"><span style="font-family: "Courier New"; mso-fareast-font-family: "Courier New";"><span style="mso-list: Ignore;">o<span style="font: 7.0pt "Times New Roman";"> </span></span></span></span><span style="font-family: Arial;">Los mayores de un año muestran un cuadro de vómitos incoercibles sin causa aparente.<span class="apple-style-span"></span></span></div><div class="MsoListParagraphCxSpMiddle" style="margin-left: 14.2pt; mso-add-space: auto; mso-layout-grid-align: none; mso-list: l6 level1 lfo5; text-align: justify; text-autospace: none; text-indent: -18.0pt; text-justify: inter-ideograph;"><span style="font-family: Symbol; mso-bidi-font-family: Symbol; mso-bidi-font-weight: bold; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span><span style="font-family: Arial;">La fase neurológica o de encefalopatía suele mantenerse durante 24-96 horas, pudiendo esperarse la recuperación funcional en los pacientes que sobreviven <b>.</b></span></div><div class="MsoListParagraphCxSpLast" style="margin-left: 14.2pt; mso-add-space: auto; mso-layout-grid-align: none; mso-list: l6 level1 lfo5; text-align: justify; text-autospace: none; text-indent: -18.0pt; text-justify: inter-ideograph;"><span style="font-family: Symbol; mso-bidi-font-family: Symbol; mso-bidi-font-weight: bold; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span><span style="font-family: Arial;">El trastorno es un <b style="mso-bidi-font-weight: normal;">daño funcional de la mitocondria del hepatocito</b>. De esta forma, existe una alteración en la -oxidación mitocondrial de ácidos grasos, no se sintetiza acetil-CoA por lo que no se activa la gluconeogénesis <i>( h i p o g l u c e m i a )</i>, no se activa el ciclo de la urea <i>(hiperamonemia)</i>, no hay síntesis de cuerpos cetónicos <i>(hipocetosis)</i>, el exceso de FFA o de FFAcil-CoA (ácidos grasos acilados con coenzima A) intramitocondriales rompen las mitocondrias hepáticas <i>(aumentan las transaminasas con microesteatosis</i> <i>hepática)</i>, el exceso de amonio da lugar a un edema cerebral por bloqueo de la ATPasa Na-K dependiente y otros bloqueos de otras vías metabólicas cerebrales <i>(encefalopatía).</i><b></b></span></div><div class="MsoNormal" style="text-align: justify; text-justify: inter-ideograph;"><br />
</div><div class="MsoNormal" style="margin-left: 18.0pt; text-align: justify; text-justify: inter-ideograph;"><b style="mso-bidi-font-weight: normal;"><span lang="ES" style="color: #3366ff; font-family: Arial; mso-ansi-language: ES;">Asa y Embarazo
</span></b><b style="mso-bidi-font-weight: normal;"><span style="color: #3366ff; font-family: Arial;"></span></b></div><div class="MsoListParagraphCxSpFirst" style="text-align: justify; text-justify: inter-ideograph;"><br />
</div><div class="MsoListParagraphCxSpLast" style="margin-left: 14.2pt; mso-add-space: auto; mso-list: l9 level1 lfo10; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><span class="apple-style-span"><span style="color: black; font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span></span><span class="apple-style-span"><span style="color: black; font-family: Arial;">Hoy en día se sabe que los salicilatos tienen efectos tanto positivos como<span style="mso-spacerun: yes;"> </span>negativos en gestantes. Esto depende de de la dosis consumida y del momento del embarazo en la que se consumen.</span></span></div><div class="MsoNormal" style="margin-left: 14.2pt; text-align: justify; text-justify: inter-ideograph;"><br />
</div><div class="MsoListParagraph" style="margin-left: 14.2pt; mso-add-space: auto; mso-list: l9 level1 lfo10; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><span class="apple-style-span"><span style="color: black; font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span></span><span class="apple-style-span"><span style="color: black; font-family: Arial;">Algunos de los beneficios reportados en mujeres gestantes que presentan el síndrome antifosfolipido demuestran que una pequeña dosis de aspirina (100mg diarios) desde antes de la concepción y durante el embarazo reduce en un 70 a 80% las posibilidades de aborto.</span></span></div><div class="MsoNormal" style="margin-left: 14.2pt; text-align: justify; text-justify: inter-ideograph;"><br />
</div><div class="MsoListParagraph" style="margin-left: 14.2pt; mso-add-space: auto; mso-list: l9 level1 lfo10; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><span class="apple-style-span"><span style="color: black; font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span></span><span class="apple-style-span"><span style="color: black; font-family: Arial;">En el síndrome antifosfolipido, los anticuerpos inhiben la producción de prostaciclina y producen agregación plaquetaria en la micro circulación venosa causando trombos y coágulos dentro de la madre y el feto. La función de los salicilatos es generar un efecto contrario aumentando la producción de prostaciclinas y evitando que se formen los trombos, actuando finalmente como un antiagregante plaquetario.1</span></span></div><div class="MsoNormal" style="margin-left: 14.2pt; text-align: justify; text-justify: inter-ideograph;"><br />
</div><div class="MsoListParagraphCxSpFirst" style="margin-left: 14.2pt; mso-add-space: auto; mso-list: l9 level1 lfo10; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><span class="apple-style-span"><span style="color: black; font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span></span><span class="apple-style-span"><span style="color: black; font-family: Arial;">A su vez se ha demostrado que el uso de los salicilatos puede afectar al sistema cardiaco, nervioso, tracto urinario y paladar del neonato. También reducen el peso promedio al nacer. Además, gracias a su efecto antiprostaglandínico, si estos son ingeridos en el primer trimestre de embarazo puede producir una prolongación de la gestación y en la labor del parto. Si se consumen en exceso, incrementan las hemorragias durante el parto y aumenta la posibilidad de mortalidad perinatal. </span></span></div><div class="MsoListParagraphCxSpMiddle" style="margin-left: 14.2pt; mso-add-space: auto; text-align: justify; text-justify: inter-ideograph;"><br />
</div><div class="MsoListParagraphCxSpLast" style="margin-left: 14.2pt; mso-add-space: auto; mso-list: l9 level1 lfo10; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><span class="apple-style-span"><span style="color: black; font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span></span><span class="apple-style-span"><span style="color: black; font-family: Arial;">Es importante recordar que si son consumidos en el último trimestre de embarazo se ha demostrado que el bebe puede desarrollar acidosis metabólica, taquipnea e hipoglucemia. </span></span></div><div class="MsoNormal" style="text-align: justify; text-justify: inter-ideograph;"><br />
</div><div class="MsoListParagraph" style="margin-left: 14.2pt; mso-add-space: auto; mso-list: l9 level1 lfo10; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><span class="apple-style-span"><span style="color: black; font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span></span><span class="apple-style-span"><span style="color: black; font-family: Arial;">Altas dosis de aspirina (3 gr/día) inhiben la contractilidad uterina y prolongan tanto la labor de parto como la gestación y aunque bajas dosis de aspirina parecen ser seguras durante todo el embarazo estas dosis pueden aumentar el riesgo de hemorragia ventricular. También se ha descrito oligohidramnios y falla renal. Por todo esto se recomienda que se debe usar aspirina hasta 8-6 semanas antes del parto.1</span></span></div><div class="MsoNormal" style="margin-left: 14.2pt; text-align: justify; text-justify: inter-ideograph;"><br />
</div><div class="MsoNormal" style="margin-left: 18.0pt; text-align: justify; text-justify: inter-ideograph;"><b style="mso-bidi-font-weight: normal;"><span lang="ES" style="color: #3366ff; font-family: Arial; mso-ansi-language: ES;">Alergias salicilatos</span></b><b style="mso-bidi-font-weight: normal;"><span style="color: #3366ff; font-family: Arial;"></span></b></div><div class="MsoListParagraphCxSpFirst" style="text-align: justify; text-justify: inter-ideograph;"><br />
</div><div class="MsoListParagraphCxSpMiddle" style="margin-bottom: 10.0pt; margin-left: 14.2pt; margin-right: 0cm; margin-top: 0cm; mso-add-space: auto; mso-layout-grid-align: none; mso-list: l3 level1 lfo9; mso-pagination: none; text-align: justify; text-autospace: none; text-indent: -18.0pt; text-justify: inter-ideograph;"><span lang="ES" style="font-family: Symbol; mso-ansi-language: ES; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span><span lang="ES" style="font-family: Arial; mso-ansi-language: ES;">Puede producir y reacciones conocidas como intolerancia, reacciones adversas a medicamentos (ram) " efecto perjuducial<span style="mso-spacerun: yes;"> </span>o indeseado que aparece en las dosis utilizadas en el hombre para el diagnóstico o la terapéutica".<span style="mso-spacerun: yes;"> </span>Son de dos tipos: A y B siendo las A mas frecuentes y predecibles, son fácilmente controlables como las sobredosis, efectos colaterales y efectos<span style="mso-spacerun: yes;"> </span>secundarios.<span style="mso-spacerun: yes;"> </span></span></div><div class="MsoListParagraphCxSpMiddle" style="margin-bottom: 10.0pt; margin-left: 14.2pt; margin-right: 0cm; margin-top: 0cm; mso-add-space: auto; mso-layout-grid-align: none; mso-list: l3 level1 lfo9; mso-pagination: none; text-align: justify; text-autospace: none; text-indent: -18.0pt; text-justify: inter-ideograph;"><span lang="ES" style="font-family: Symbol; mso-ansi-language: ES; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span><span lang="ES" style="font-family: Arial; mso-ansi-language: ES;">Y tipo B, son reacciones no frecuentes impredecibles y no suelen estar relacionados con los efectos farmacológicos<span style="mso-spacerun: yes;"> </span>ni con la dosis,<span style="mso-spacerun: yes;"> </span>ocurren en sujetos con sensibilidad inmunologica, intolerancia ( pequeña dosis = efecto grande ), y alergia (anafilaxia tras la toma de un antibiotico por ejemplo). </span></div><div class="MsoListParagraphCxSpMiddle" style="margin-bottom: 10.0pt; margin-left: 14.2pt; margin-right: 0cm; margin-top: 0cm; mso-add-space: auto; mso-layout-grid-align: none; mso-list: l3 level1 lfo9; mso-pagination: none; text-align: justify; text-autospace: none; text-indent: -18.0pt; text-justify: inter-ideograph;"><span lang="ES" style="font-family: Symbol; mso-ansi-language: ES; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span><span lang="ES" style="font-family: Arial; mso-ansi-language: ES;">Estas alergias estan mediadas por una hipersensibilidad<span style="mso-spacerun: yes;"> </span>tanto humorales como celular y tienen una categoria tipo 1 mediadas por inmunoglobulinas E tipo2, por inmunocomplejos tipo3, y por hipersensibilidad retardada en cada caso; la respuesta puede ir dirigida a el medicamento o<span style="mso-spacerun: yes;"> </span>a uno de sus metabolitos, las cuales son reconocidas por el sistema inmunológico como un químico extraño y se forman la reacciones<span style="mso-spacerun: yes;"> </span>tipo reactividad cruzada.<span style="mso-spacerun: yes;"> </span></span></div><div class="MsoListParagraphCxSpMiddle" style="margin-bottom: 10.0pt; margin-left: 14.2pt; margin-right: 0cm; margin-top: 0cm; mso-add-space: auto; mso-layout-grid-align: none; mso-list: l3 level1 lfo9; mso-pagination: none; text-align: justify; text-autospace: none; text-indent: -18.0pt; text-justify: inter-ideograph;"><span lang="ES" style="font-family: Symbol; mso-ansi-language: ES; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span><span lang="ES" style="font-family: Arial; mso-ansi-language: ES;">Respecto a los factores de riesgo que pueden generar una intolerancia a los AINES estan: 1 sexo, 2 la atopia, 3 historia familiar de intolerancia a los AINES. El predominio es en mujeres mas que en hombres además tiene una diferencia en la forma de presentación de la enfermedad en hombres y en mujeres, en las mujeres los síntomas aparecen mas hacia la temprana edad y fuera de eso tienen una evolución mas progresiva y severa (atopia: reacciones alérgicas que tienen como respuesta liberación de igE desencadenada por mucha clase de estimulos<span style="mso-spacerun: yes;"> </span>frio polvo calor...). </span></div><div class="MsoListParagraphCxSpMiddle" style="margin-left: 14.2pt; mso-add-space: auto; mso-list: l3 level1 lfo9; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><span style="font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span><span lang="ES" style="font-family: Arial; mso-ansi-language: ES;">También hay un factor genético, se ha encontrado una asociación entre ser portador del alelo AHLA DRB1-11 y la presencia de reacciones anafilactoides tras la toma de AAS o AINES.</span><span style="font-family: Arial;"></span></div><div class="MsoListParagraphCxSpLast" style="text-align: justify; text-justify: inter-ideograph;"><br />
</div><div class="MsoNormal" style="text-align: justify; text-justify: inter-ideograph;"><br />
</div><div class="MsoNormal" style="margin-left: 18.0pt; text-align: justify; text-justify: inter-ideograph;"><b style="mso-bidi-font-weight: normal;"><span lang="ES" style="color: #0080ff; font-family: Arial; mso-ansi-language: ES;">Tratamiento</span></b><b style="mso-bidi-font-weight: normal;"><span style="color: #0080ff; font-family: Arial;"></span></b></div><div class="MsoNormal" style="margin-left: 14.2pt; text-align: justify; text-justify: inter-ideograph;"><br />
</div><div class="MsoListParagraphCxSpFirst" style="margin-left: 14.2pt; mso-add-space: auto; mso-list: l0 level1 lfo1; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><span class="apple-style-span"><span style="color: black; font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span></span><span class="apple-style-span"><span style="color: black; font-family: Arial;">Requiere atención inmediata.</span></span></div><div class="MsoListParagraphCxSpMiddle" style="margin-left: 14.2pt; mso-add-space: auto; mso-list: l0 level1 lfo1; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><span class="apple-style-span"><span style="color: black; font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span></span><span class="apple-style-span"><span style="color: black; font-family: Arial;">Se le debe hacer exámenes de sangre para medir el equilibrio acido-base y los electrolitos</span></span></div><div class="MsoListParagraphCxSpMiddle" style="margin-left: 14.2pt; mso-add-space: auto; mso-list: l0 level1 lfo1; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><span class="apple-style-span"><span style="color: black; font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span></span><span class="apple-style-span"><span style="color: black; font-family: Arial;">buscar disminuir la absorción del fármaco en el intestino con el carbón activado o lavado gastrointestinal.</span></span></div><div class="MsoListParagraphCxSpMiddle" style="margin-left: 14.2pt; mso-add-space: auto; mso-list: l0 level1 lfo1; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><span class="apple-style-span"><span style="color: black; font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span></span><span class="apple-style-span"><span style="color: black; font-family: Arial;">Soluciones intravenosas para disminuir la fiebre. </span></span></div><div class="MsoListParagraphCxSpMiddle" style="margin-left: 14.2pt; mso-add-space: auto; mso-list: l0 level1 lfo1; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><span class="apple-style-span"><span style="color: black; font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span></span><span class="apple-style-span"><span style="color: black; font-family: Arial;">Si el síntoma inicial es acidosis, hay que corregir el Ph bajo en sangre porque hace que el salicilato se desplace de la sangre al cerebro y otros tejidos, introduciendo bicarbonato.</span></span></div><div class="MsoListParagraphCxSpMiddle" style="margin-left: 14.2pt; mso-add-space: auto; mso-list: l0 level1 lfo1; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><span class="apple-style-span"><span style="color: black; font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span></span><span class="apple-style-span"><span style="color: black; font-family: Arial;">La eliminación de la cetosis y<span style="mso-spacerun: yes;"> </span>de la hipoglucemia es esencial mediante soluciones glucosadas, sin embargo, la cetosis desaparece lentamente.</span></span></div><div class="MsoListParagraphCxSpMiddle" style="margin-left: 14.2pt; mso-add-space: auto; mso-list: l0 level1 lfo1; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><span class="apple-style-span"><span style="color: black; font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span></span><span class="apple-style-span"><span style="color: black; font-family: Arial;"><span style="mso-spacerun: yes;"> </span>Si hay deficiencia de potasio hay que agregarlo a la solución.</span></span></div><div class="MsoListParagraphCxSpLast" style="margin-left: 14.2pt; mso-add-space: auto; mso-list: l0 level1 lfo1; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><span class="apple-style-span"><span style="font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span></span><span class="apple-style-span"><span style="font-family: Arial;">Hay que inducir a una diuresis, ya que el pKa del acido salicílico se presta para facilitar la eliminación por medio de la alcalinización de la orina. </span></span></div>intoxicación por salicilatoshttp://www.blogger.com/profile/11916964230815399927noreply@blogger.com0tag:blogger.com,1999:blog-6732325050545632670.post-47882375111765729722011-11-05T20:49:00.001-07:002011-11-05T20:49:47.037-07:00Bibliografía<style>
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Pg 1245.</span></div><div class="MsoNormal" style="margin-left: 21.3pt; text-indent: -21.3pt;"><span lang="EN-US" style="color: black; font-family: "Times New Roman"; font-size: 12.0pt; line-height: 115%; mso-ansi-language: EN-US;">De Vivo, D.C. <i style="mso-bidi-font-style: normal;"><u>Reye´s síndrome and associated metabolic encephalopathies</u></i>. Pediatric Neurology. Fishman M.A. Pgs 203-217. Grune and Stratton. New York. 1986.</span></div><div class="MsoNormal" style="margin-left: 21.3pt; text-indent: -21.3pt;"><span lang="ES-CO" style="color: black; font-family: "Times New Roman"; font-size: 12.0pt; line-height: 115%;">Devlin, T., </span><span lang="ES-CO" style="font-family: "Times New Roman"; font-size: 12.0pt; line-height: 115%;">Bioquímica: libro de texto con aplicaciones clínicas. </span><span lang="EN-US" style="font-family: "Times New Roman"; font-size: 12.0pt; line-height: 115%; mso-ansi-language: EN-US;">Reverte. 2004. 4<sup>a</sup> Edición. Pg 716.<span style="color: black;"></span></span></div><div class="MsoNormal" style="margin-left: 21.3pt; text-indent: -21.3pt;"><span lang="EN-US" style="color: black; font-family: "Times New Roman"; font-size: 12.0pt; line-height: 115%; mso-ansi-language: EN-US;">Glassman, M.; Tahan, S,; Hillermeir, C. et al. Pancreatitis <i style="mso-bidi-font-style: normal;"><u>in patients with Reye´s syndrome.</u></i> J. Clin. Gastroenterol. 1981; 3: 165-169.</span></div><div class="ecxmsonormal" style="margin-left: 21.3pt; text-indent: -21.3pt;"><span lang="ES-CO" style="color: black;"><a href="http://www.google.com/search?tbo=p&tbm=bks&q=inauthor:%22Lewis+R.+Goldfrank%22&source=gbs_metadata_r&cad=10"><span lang="EN-US" style="color: black; mso-ansi-language: EN-US; text-decoration: none; text-underline: none;">Goldfrank</span></a></span><span lang="EN-US" style="color: black; mso-ansi-language: EN-US;">, R.L.</span><span lang="EN-US" style="mso-ansi-language: EN-US;">; <span style="mso-spacerun: yes;"> </span>Flomenbaum, N, et al. <i style="mso-bidi-font-style: normal;"><u>Goldfrank's Toxicologic Emergencies.</u></i> McGraw-Hill Professional, 2006. 8<sup>a</sup> Edición. Cap. 35, pag: 554 - 555 <span class="addmd"></span></span></div><div class="MsoNormal" style="margin-left: 21.3pt; text-indent: -21.3pt;"><span class="addmd"><span lang="EN-US" style="font-family: "Times New Roman"; font-size: 12.0pt; line-height: 115%; mso-ansi-language: EN-US;">Goodman, L.S;<span style="mso-spacerun: yes;"> </span>Gilman, A;<span style="mso-spacerun: yes;"> </span>Brunton, L, et al<i style="mso-bidi-font-style: normal;">.</i> </span></span><span lang="ES-CO" style="color: black; font-family: "Times New Roman"; font-size: 12.0pt; line-height: 115%;"><a href="http://www.google.com/search?tbo=p&tbm=bks&q=bibliogroup:%22Goodman+and+Gilman%22s+the+Pharmacological+Basis+of+Therapeutics%22&source=gbs_metadata_r&cad=8"><i><span style="color: black;">Goodman and Gilman´s the Pharmacological Basis of Therapeutics</span></i></a>. </span><span lang="ES-CO" style="font-family: "Times New Roman"; font-size: 12.0pt; line-height: 115%;">McGraw-Hill<span style="mso-spacerun: yes;"> </span>2006. 11<span class="addmd">ª Edición. 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Pg. 662.</span></span></div><div class="MsoNormal" style="margin-left: 21.3pt; text-indent: -21.3pt;"><span class="addmd"><span lang="EN-US" style="font-family: "Times New Roman"; font-size: 12.0pt; line-height: 115%; mso-ansi-language: EN-US;">Goodman, L.S;<span style="mso-spacerun: yes;"> </span>Gilman, A;<span style="mso-spacerun: yes;"> </span>Brunton, L, et al<i style="mso-bidi-font-style: normal;">.</i> </span></span><span lang="ES-CO" style="color: black; font-family: "Times New Roman"; font-size: 12.0pt; line-height: 115%;"><a href="http://www.google.com/search?tbo=p&tbm=bks&q=bibliogroup:%22Goodman+and+Gilman%22s+the+Pharmacological+Basis+of+Therapeutics%22&source=gbs_metadata_r&cad=8"><i><span lang="EN-US" style="color: black; mso-ansi-language: EN-US;">Goodman and Gilman´s the Pharmacological Basis of Therapeutics</span></i></a></span><span lang="EN-US" style="color: black; font-family: "Times New Roman"; font-size: 12.0pt; line-height: 115%; mso-ansi-language: EN-US;">. </span><span lang="EN-US" style="font-family: "Times New Roman"; font-size: 12.0pt; line-height: 115%; mso-ansi-language: EN-US;">McGraw-Hill<span style="mso-spacerun: yes;"> </span>2006. </span><span lang="ES-CO" style="font-family: "Times New Roman"; font-size: 12.0pt; line-height: 115%;">12<span class="addmd">ª Edición. <span style="mso-spacerun: yes;"> </span>Cap. 34.</span></span></div><div class="MsoNormal" style="margin-left: 21.3pt; text-indent: -21.3pt;"><span class="addmd"><span lang="EN-US" style="font-family: "Times New Roman"; font-size: 12.0pt; line-height: 115%; mso-ansi-language: EN-US;">Marshall, L.F.; Shafiro, H.M., et al. <i style="mso-bidi-font-style: normal;"><u>Pentobarbital therapy for intracranial hypertension in metabolic coma.</u></i> Critical Care Medicine, 1987; 6: 1-5.</span></span></div><div class="MsoNormal" style="margin-left: 21.3pt; text-indent: -21.3pt;"><span lang="ES-CO" style="color: black; font-family: "Times New Roman"; font-size: 12.0pt; line-height: 115%;">Palencia, R. <i style="mso-bidi-font-style: normal;"><u>Pediatria Extrahospitalaria: Sindrome de Reye.</u></i> </span><span lang="ES-CO" style="font-family: "Times New Roman"; font-size: 12.0pt; line-height: 115%; mso-fareast-language: ES-CO;">Bol Pediatr 1989. </span><span lang="EN-US" style="font-family: "Times New Roman"; font-size: 12.0pt; line-height: 115%; mso-ansi-language: EN-US; mso-fareast-language: ES-CO;">Volúmen 30: 7 – 13.</span></div><div class="MsoNormal" style="margin-left: 21.3pt; text-indent: -21.3pt;"><span lang="EN-US" style="color: black; font-family: "Times New Roman"; font-size: 12.0pt; line-height: 115%; mso-ansi-language: EN-US;">Rogers, M.</span><span lang="EN-US" style="font-family: "Times New Roman"; font-size: 12.0pt; line-height: 115%; mso-ansi-language: EN-US; mso-fareast-language: ES-CO;">; Nichols, D., et al. <i style="mso-bidi-font-style: normal;"><u>Textbook of Pediatric Intensive Care</u></i>. Williams & Wilkins.1996. Reye and Methabolic Encephalopathies. Cap. 23. Pgs 779-807.</span></div><div class="MsoNormal" style="margin-left: 21.3pt; text-indent: -21.3pt;"><span lang="EN-US" style="color: black; font-family: "Times New Roman"; font-size: 12.0pt; line-height: 115%; mso-ansi-language: EN-US;">Schubert, W.</span><span lang="EN-US" style="font-family: "Times New Roman"; font-size: 12.0pt; line-height: 115%; mso-ansi-language: EN-US; mso-fareast-language: ES-CO;">K.; <i style="mso-bidi-font-style: normal;"><u>Treatment controversies in Reye´s síndrome</u></i>. J.Natl. 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</div><div class="MsoNormal" style="margin-left: 21.3pt; text-indent: -21.3pt;"><br />
</div>intoxicación por salicilatoshttp://www.blogger.com/profile/11916964230815399927noreply@blogger.com0tag:blogger.com,1999:blog-6732325050545632670.post-84955864972194355172011-11-05T20:41:00.000-07:002011-11-05T20:41:52.384-07:00TIPS<style>
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<div align="center" class="MsoNormal" style="color: purple; text-align: center;"><b style="mso-bidi-font-weight: normal;"><span lang="ES" style="font-family: Arial; font-size: 20.0pt; mso-ansi-language: ES; mso-effects-reflection-align: bottomleft; mso-effects-reflection-angdirection: 5400000; mso-effects-reflection-angfadedirection: 5400000; mso-effects-reflection-anglekx: 0; mso-effects-reflection-angleky: 0; mso-effects-reflection-dpidistance: .079pt; mso-effects-reflection-dpiradius: 1.0pt; mso-effects-reflection-pctalphaend: 0%; mso-effects-reflection-pctalphastart: 28.0%; mso-effects-reflection-pctendpos: 45.0%; mso-effects-reflection-pctstartpos: 0%; mso-effects-reflection-pctsx: 100.0%; mso-effects-reflection-pctsy: -100.0%; mso-style-textfill-fill-gradientfill-shade-linearshade-angle: 5400000; mso-style-textfill-fill-gradientfill-shade-linearshade-fscaled: no; mso-style-textfill-fill-gradientfill-shadetype: linear; mso-style-textfill-fill-gradientfill-stoplist: "0 \#381563 7 100000 shade=20000 satm=245000\,43000 \#7B34D2 7 100000 satm=255000\,48000 \#7230C3 7 100000 shade=85000 satm=255000\,100000 \#381563 7 100000 shade=20000 satm=245000"; mso-style-textfill-type: gradient; mso-style-textoutline-fill-alpha: 100.0%; mso-style-textoutline-fill-color: #5C437A; mso-style-textoutline-fill-colortransforms: "shade=50000 satm=120000"; mso-style-textoutline-fill-themecolor: accent4; mso-style-textoutline-outlinestyle-align: center; mso-style-textoutline-outlinestyle-compound: simple; mso-style-textoutline-outlinestyle-dash: solid; mso-style-textoutline-outlinestyle-dpiwidth: .709pt; mso-style-textoutline-outlinestyle-join: round; mso-style-textoutline-outlinestyle-linecap: flat; mso-style-textoutline-outlinestyle-pctmiterlimit: 0%; mso-style-textoutline-type: solid; text-transform: uppercase;">TIPS</span></b></div><div class="MsoNormal" style="text-align: justify; text-justify: inter-ideograph;"><br />
</div><div class="MsoListParagraphCxSpFirst" style="mso-list: l0 level1 lfo1; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><b style="mso-bidi-font-weight: normal;"><span lang="ES" style="color: #0080ff; font-family: Arial; mso-ansi-language: ES; mso-fareast-font-family: Arial;"><span style="mso-list: Ignore;">1.<span style="font: 7.0pt "Times New Roman";"> </span></span></span></b><b style="mso-bidi-font-weight: normal;"><span lang="ES" style="color: #0080ff; font-family: Arial; mso-ansi-language: ES;">Quienes los usan?</span></b></div><div class="MsoListParagraphCxSpLast" style="text-align: justify; text-justify: inter-ideograph;"><span lang="ES" style="font-family: Arial; mso-ansi-language: ES;">Es recomendado en dosis variables según el caso. Se usa como antiinflamatorio y analgésico en dolor agudo y enfermedad crónica, cómo anti agregante plaquetario en enfermedades isquémicas y en madres gestantes con síndrome anti fosfolípido para evitar trombos dentro de la madre y el feto. </span></div><div class="MsoNormal" style="text-align: justify; text-justify: inter-ideograph;"><br />
</div><div class="MsoListParagraphCxSpFirst" style="mso-list: l0 level1 lfo1; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><b style="mso-bidi-font-weight: normal;"><span style="color: #0080ff; font-family: Arial; mso-fareast-font-family: Arial;"><span style="mso-list: Ignore;">2.<span style="font: 7.0pt "Times New Roman";"> </span></span></span></b><b style="mso-bidi-font-weight: normal;"><span lang="ES" style="color: #0080ff; font-family: Arial; mso-ansi-language: ES;">
Quien es la Aspirina?
</span></b><b style="mso-bidi-font-weight: normal;"><span style="color: #0080ff; font-family: Arial;"></span></b></div><div class="MsoListParagraphCxSpLast" style="text-align: justify; text-justify: inter-ideograph;"><span style="font-family: Arial;">La aspirina cuyo componente principal es el acido acetil salicílico, pertenece al grupo de los AINES, <span class="apple-style-span"><span style="color: black;">Los salicilatos se encuentran disponibles en grageas, capsulas, polvo, tabletas efervescentes, preparación liquida para ingestión, supositorios, aceites, cremas y<span style="mso-spacerun: yes;"> </span>lociones para aplicación tópica y existen diferentes presentaciones del acido acetil salicílico que varían en formulas, dosis, laboratorios y nombres.</span></span></span></div><div class="MsoNormal" style="text-align: justify; text-justify: inter-ideograph;"><br />
</div><div class="MsoListParagraphCxSpFirst" style="mso-list: l0 level1 lfo1; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><b style="mso-bidi-font-weight: normal;"><span style="color: #0080ff; font-family: Arial; mso-fareast-font-family: Arial;"><span style="mso-list: Ignore;">3.<span style="font: 7.0pt "Times New Roman";"> </span></span></span></b><b style="mso-bidi-font-weight: normal;"><span lang="ES" style="color: #0080ff; font-family: Arial; mso-ansi-language: ES;">Mecanismo de acción?
</span></b><b style="mso-bidi-font-weight: normal;"><span style="color: #0080ff; font-family: Arial;"></span></b></div><div class="MsoListParagraphCxSpMiddle" style="text-align: justify; text-justify: inter-ideograph;"><span style="font-family: Arial;">Es un inhibidor no selectivo de las ciclo oxigenasas COX 1 y COX 2, inhibiendo con esto la síntesis de prostaglandinas (PG) y tromboxanos (TX).</span></div><div class="MsoListParagraphCxSpMiddle" style="text-align: justify; text-justify: inter-ideograph;"><br />
</div><div class="MsoListParagraphCxSpMiddle" style="mso-list: l0 level1 lfo1; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><b style="mso-bidi-font-weight: normal;"><span style="color: #0080ff; font-family: Arial; mso-fareast-font-family: Arial;"><span style="mso-list: Ignore;">4.<span style="font: 7.0pt "Times New Roman";"> </span></span></span></b><b style="mso-bidi-font-weight: normal;"><span lang="ES" style="color: #0080ff; font-family: Arial; mso-ansi-language: ES;">Cual es la utilidad de la COX?
</span></b><b style="mso-bidi-font-weight: normal;"><span style="color: #0080ff; font-family: Arial;"></span></b></div><div class="MsoListParagraphCxSpLast" style="text-align: justify; text-justify: inter-ideograph;"><span style="font-family: Arial;">La reacción de la<span style="mso-spacerun: yes;"> </span>Ciclooxigenasa tiene como sustrato al ácido araquidónico<span style="mso-spacerun: yes;"> </span>que a su vez es un derivado de ácidos grasos esenciales y fosfolípidos de membrana y produce la síntesis de Eicosanoides como la PGG2, que por reacción de una Peroxidasa produce PGH2 y reacciona con enzimas dependiendo del tejido en el que se encuentre,<span style="mso-spacerun: yes;"> </span>haciendo la síntesis de: TX2 y PGI1 (prostaciclina) que tienen una función antagónica.</span></div><div style="margin-left: 72.0pt; mso-list: l2 level1 lfo5; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><span lang="ES" style="font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span><span lang="ES" style="font-family: Arial;">La PGI1: es producido por células endoteliales vasculares, inhibe la agregación plaquetaria y causa vasodilatación.</span></div><div style="margin-left: 72.0pt; mso-list: l2 level1 lfo5; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><span lang="ES" style="font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span><span lang="ES" style="font-family: Arial;">El TX2: es producido por las plaquetas, estimula la agregación plaquetaria y causa vasoconstricción.</span></div><div class="MsoListParagraphCxSpFirst" style="mso-list: l0 level1 lfo1; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><b style="mso-bidi-font-weight: normal;"><span style="color: #0080ff; font-family: Arial; mso-fareast-font-family: Arial;"><span style="mso-list: Ignore;">5.<span style="font: 7.0pt "Times New Roman";"> </span></span></span></b><b style="mso-bidi-font-weight: normal;"><span lang="ES" style="color: #0080ff; font-family: Arial; mso-ansi-language: ES;">Contraindicaciones
</span></b><b style="mso-bidi-font-weight: normal;"><span style="color: #0080ff; font-family: Arial;"></span></b></div><div class="MsoListParagraphCxSpMiddle" style="line-height: 115%; margin-bottom: 10.0pt; margin-left: 72.0pt; margin-right: 0cm; margin-top: 0cm; mso-add-space: auto; mso-list: l4 level1 lfo6; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><span class="apple-style-span"><span style="color: black; font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span></span><span class="apple-style-span"><span style="color: black; font-family: Arial;">Hipersensibilidad conocida a la sustancia activa u otros salicilatos.</span></span></div><div class="MsoListParagraphCxSpMiddle" style="line-height: 115%; margin-bottom: 10.0pt; margin-left: 72.0pt; margin-right: 0cm; margin-top: 0cm; mso-add-space: auto; mso-list: l4 level1 lfo6; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><span class="apple-style-span"><span style="color: black; font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span></span><span class="apple-style-span"><span style="color: black; font-family: Arial;">Diátesis hemorrágica: conjunto de desórdenes que ocurren como resultado de anormalidades en el proceso hemostático normal y como consecuencia de una ruptura del equilibrio</span></span><span class="apple-style-span"><span style="color: black; font-family: Arial; mso-fareast-font-family: "MS Gothic";">
</span></span><span class="apple-style-span"><span style="color: black; font-family: Arial;">hemostasia-fibrinólisis, que favorece el sangrado. </span></span><span class="apple-style-span"><span style="font-family: Arial;">(Fibrinólisis:</span></span><span style="font-family: Arial;"> consiste en la degradación de las redes de </span><a href="http://es.wikipedia.org/wiki/Fibrina" title="Fibrina"><span style="color: windowtext; font-family: Arial; text-decoration: none; text-underline: none;">fibrina</span></a><span style="font-family: Arial;"> formadas en el proceso de </span><a href="http://es.wikipedia.org/wiki/Coagulaci%C3%B3n" title="Coagulación"><span style="color: windowtext; font-family: Arial; text-decoration: none; text-underline: none;">coagulación</span></a><span style="font-family: Arial;"> sanguínea, evitando la formación de </span><a href="http://es.wikipedia.org/wiki/Trombosis" title="Trombosis"><span style="color: windowtext; font-family: Arial; text-decoration: none; text-underline: none;">trombos</span></a><span style="font-family: Arial;">).<span class="apple-style-span"><span style="color: black;"></span></span></span></div><div class="MsoListParagraphCxSpMiddle" style="line-height: 115%; margin-bottom: 10.0pt; margin-left: 72.0pt; margin-right: 0cm; margin-top: 0cm; mso-add-space: auto; mso-list: l4 level1 lfo6; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><span class="apple-style-span"><span style="color: black; font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span></span><span class="apple-style-span"><span style="color: black; font-family: Arial;">Ulcera gástrica o duodenal.</span></span></div><div class="MsoListParagraphCxSpMiddle" style="line-height: 115%; margin-bottom: 10.0pt; margin-left: 72.0pt; margin-right: 0cm; margin-top: 0cm; mso-add-space: auto; mso-list: l4 level1 lfo6; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><span class="apple-style-span"><span style="color: black; font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span></span><span class="apple-style-span"><span style="color: black; font-family: Arial;">Embarazo y lactancia.</span></span></div><div class="MsoListParagraphCxSpMiddle" style="line-height: 115%; margin-bottom: 10.0pt; margin-left: 72.0pt; margin-right: 0cm; margin-top: 0cm; mso-add-space: auto; mso-list: l4 level1 lfo6; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><span style="color: black; font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span><span class="apple-style-span"><span style="color: black; font-family: Arial;">Uso simultaneo con anticoagulantes.</span></span><span style="color: black; font-family: Arial;"></span></div><div class="MsoListParagraphCxSpMiddle" style="text-align: justify; text-justify: inter-ideograph;"><br />
</div><div class="MsoListParagraphCxSpMiddle" style="mso-list: l0 level1 lfo1; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><b style="mso-bidi-font-weight: normal;"><span style="color: #0080ff; font-family: Arial; mso-fareast-font-family: Arial;"><span style="mso-list: Ignore;">6.<span style="font: 7.0pt "Times New Roman";"> </span></span></span></b><b style="mso-bidi-font-weight: normal;"><span lang="ES" style="color: #0080ff; font-family: Arial; mso-ansi-language: ES;">Dosis terapéuticas tóxicas
</span></b><b style="mso-bidi-font-weight: normal;"><span style="color: #0080ff; font-family: Arial;"></span></b></div><div class="MsoListParagraphCxSpMiddle" style="text-align: justify; text-justify: inter-ideograph;"><br />
</div><div class="MsoListParagraphCxSpMiddle" style="line-height: 115%; margin-bottom: 10.0pt; mso-add-space: auto; mso-list: l3 level1 lfo2; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><span style="font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span><span style="font-family: Arial;">Normalmente en enfermedades crónicas se recomienda 650 mg, cada cuatro horas, siendo el rango terapéutico de concentración en sangre de 15-30mg/dl. </span></div><div class="MsoListParagraphCxSpMiddle" style="line-height: 115%; margin-bottom: 10.0pt; mso-add-space: auto; mso-list: l3 level1 lfo2; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><span style="font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span><span style="font-family: Arial;">Las concentraciones mayores de 30 mg/dl en plasma es indicativo para aparición de síntomas de toxicidad.</span></div><div class="MsoListParagraphCxSpLast" style="line-height: 115%; margin-bottom: 10.0pt; mso-add-space: auto; mso-list: l3 level1 lfo2; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><span style="font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span><span style="font-family: Arial;">La intoxicación por salicilatos tiene niveles de toxicidad dividiéndose en: </span></div><div class="MsoNormal" style="line-height: 115%; margin-bottom: 10.0pt; margin-left: 63.8pt; margin-right: 0cm; margin-top: 0cm; text-align: justify; text-justify: inter-ideograph;"><u><span style="font-family: Arial;">Toxicidad leve</span></u><span style="font-family: Arial;"> de 150 a 200 mg por kg.</span></div><div class="MsoNormal" style="line-height: 115%; margin-bottom: 10.0pt; margin-left: 63.8pt; margin-right: 0cm; margin-top: 0cm; text-align: justify; text-justify: inter-ideograph;"><u><span style="font-family: Arial;">Moderada</span></u><span style="font-family: Arial;"> de 200 a 300 mg por kg.</span></div><div class="MsoNormal" style="line-height: 115%; margin-bottom: 10.0pt; margin-left: 63.8pt; margin-right: 0cm; margin-top: 0cm; text-align: justify; text-justify: inter-ideograph;"><u><span style="font-family: Arial;">Grave</span></u><span style="font-family: Arial;"> de 300 a 500 mg por kg.</span></div><div class="MsoNormal" style="line-height: 115%; margin-bottom: 10.0pt; margin-left: 63.8pt; margin-right: 0cm; margin-top: 0cm; text-align: justify; text-justify: inter-ideograph;"><u><span style="font-family: Arial;">Potencialmente mortal</span></u><span style="font-family: Arial;"> mayor de 500 mg por kg.</span></div><div class="MsoListParagraph" style="line-height: 115%; margin-bottom: 10.0pt; mso-add-space: auto; mso-list: l1 level1 lfo3; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><span style="font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span><span style="font-family: Arial;">Intoxicación por salicilatos tópicos que no presentan mayor riesgo por su baja tasa de absorción, a menos que se ingiera, porque el metil salicílico se absorbe rápidamente por el tracto gastrointestinal al ser hidrolizado rápidamente a salicilatos libres.</span></div><div class="MsoNormal" style="text-align: justify; text-justify: inter-ideograph;"><br />
</div><div class="MsoListParagraphCxSpFirst" style="mso-list: l0 level1 lfo1; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><b style="mso-bidi-font-weight: normal;"><span style="color: #0080ff; font-family: Arial; mso-fareast-font-family: Arial;"><span style="mso-list: Ignore;">7.<span style="font: 7.0pt "Times New Roman";"> </span></span></span></b><b style="mso-bidi-font-weight: normal;"><span lang="ES" style="color: #0080ff; font-family: Arial; mso-ansi-language: ES;">Cuales son los mecanismos de toxicidad
</span></b><b style="mso-bidi-font-weight: normal;"><span style="color: #0080ff; font-family: Arial;"></span></b></div><div class="MsoListParagraphCxSpMiddle" style="text-align: justify; text-justify: inter-ideograph;"><br />
</div><div class="MsoListParagraphCxSpMiddle" style="line-height: 115%; margin-bottom: 10.0pt; mso-add-space: auto; mso-list: l5 level1 lfo4; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><span style="font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span><span style="font-family: Arial;">Al haber sobredosis de salicilatos, la sintomatología ocurre dentro de las dos horas posteriores a la ingestión habiendo un pico de concentración en plasma a las 4 o 6 horas.</span></div><div class="MsoListParagraphCxSpMiddle" style="line-height: 115%; margin-bottom: 10.0pt; mso-add-space: auto; mso-list: l5 level1 lfo4; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><span style="font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span><span style="font-family: Arial;">El acido acetil salicílico se hidroliza<span style="mso-spacerun: yes;"> </span>por esterasas en la mucosa del tracto gastrointestinal para entrar a la circulación sistémica.</span></div><div class="MsoListParagraphCxSpMiddle" style="line-height: 115%; margin-bottom: 10.0pt; mso-add-space: auto; mso-list: l5 level1 lfo4; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><span style="font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span><span style="font-family: Arial;">Tienen vida media más larga en concentraciones tóxicas de hasta 20 horas mientras normalmente son de 2 a 4 horas. </span></div><div class="MsoListParagraphCxSpMiddle" style="line-height: 115%; margin-bottom: 10.0pt; mso-add-space: auto; mso-list: l5 level1 lfo4; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><span style="font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span><span style="font-family: Arial;">En concentraciones toxicas hay una disminución en la unión de la albúmina desde 90% a 75% y la proporción del salicilato total unido se disminuye a medida que las concentraciones en plasma aumentan, habiendo más concentración libre. </span></div><div class="MsoListParagraphCxSpMiddle" style="line-height: 115%; margin-bottom: 10.0pt; mso-add-space: auto; mso-list: l5 level1 lfo4; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><span style="font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span><span style="font-family: Arial;">El salicilato compite con una variedad de compuestos por los sitios de unión a las proteínas saturando los sitios de unión de las proteínas plasmáticas, modifica la unión de otros fármacos a la albúmina al acetilarla; también acetila hormonas, el ADN, la hemoglobina y otras proteínas.</span></div><div class="MsoListParagraphCxSpMiddle" style="line-height: 115%; margin-bottom: 10.0pt; mso-add-space: auto; mso-list: l5 level1 lfo4; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><span style="font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span><span style="font-family: Arial;">El grupo funcional acetilo del acido acético se une a muchas moléculas orgánicas haciendo que sea mayor su habilidad para cruzar la barrera hematoencefálica, así alcanza al cerebro más rápidamente incrementando los efectos.</span></div><div class="MsoListParagraphCxSpMiddle" style="line-height: 115%; margin-bottom: 10.0pt; mso-add-space: auto; mso-list: l5 level1 lfo4; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><span style="font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span><span style="font-family: Arial;">En el ADN se acetila la histona por las acetiltransferasas generando la expansión de la cromatina permitiendo la transcripción génica (porque cuando se quita por desacetilasas se condensa, impidiendo la transcripción)</span></div><div class="MsoListParagraphCxSpMiddle" style="line-height: 115%; margin-bottom: 10.0pt; margin-left: 35.45pt; margin-right: 0cm; margin-top: 0cm; mso-add-space: auto; mso-list: l5 level1 lfo4; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><span style="font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span><span style="font-family: Arial;">Las ingestiones masivas retrasan el vaciamiento gástrico provocando mayores concentraciones plasmáticas durante horas después de la ingestión prolongando la vida media.</span></div><div class="MsoListParagraphCxSpLast" style="line-height: 115%; margin-bottom: 10.0pt; mso-add-space: auto; mso-list: l5 level1 lfo4; text-align: justify; text-indent: -18.0pt; text-justify: inter-ideograph;"><span style="font-family: Symbol; mso-bidi-font-family: Symbol; mso-fareast-font-family: Symbol;"><span style="mso-list: Ignore;">·<span style="font: 7.0pt "Times New Roman";"> </span></span></span><span style="font-family: Arial;"><span style="mso-spacerun: yes;"> </span>La eliminación ocurre entre 15 y 30 horas y es dosis-dependiente como resultado de la capacidad limitada del hígado para formar acido salicilurico y glucurónico fenólico para excretar, la consecuencia es una concentración mayor de acetil salicílico libre.</span></div>intoxicación por salicilatoshttp://www.blogger.com/profile/11916964230815399927noreply@blogger.com0tag:blogger.com,1999:blog-6732325050545632670.post-30127247823327689282011-11-05T07:23:00.000-07:002011-11-05T07:23:39.116-07:00Entrevista Especialistas<div class="separator" style="clear: both; text-align: center;"><iframe allowfullscreen='allowfullscreen' webkitallowfullscreen='webkitallowfullscreen' mozallowfullscreen='mozallowfullscreen' width='320' height='266' src='https://www.blogger.com/video.g?token=AD6v5dw-930CmgIWXL2WNUUqd-kU8zE1fZ29wuuZx2jkV3ZajgWXziz3svNFgaLc2aS3YxtAJLcI4K-j5M48IquNnA' class='b-hbp-video b-uploaded' frameborder='0'></iframe></div>intoxicación por salicilatoshttp://www.blogger.com/profile/11916964230815399927noreply@blogger.com0tag:blogger.com,1999:blog-6732325050545632670.post-66937061946601438732011-11-04T19:47:00.000-07:002011-11-04T19:47:26.976-07:00Entrevistas<div class="separator" style="clear: both; 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